Improving media fragment integration in emerging web formats

The media components integrated into multimedia presentations are typically entire files. At times the media component desired for integration, either as a navigation destination or as coordinate presentation, is a part of a file, or what we call a fragment. Basic media fragment integration has long been implemented in hypermedia systems, but not to the degree envisioned by hypermedia research. The current emergence of several XML-based formats is beginning to extend the possibilities for media fragment integration on a large scale. This paper presents a set of requirements for media fragment integration, describes how standards currently meet some of these requirements and proposes extensions to these standards for meeting remaining requirements

Ancient diversification of Hyposmocoma moths in Hawaii

Island biogeography is fundamental to understanding colonization, speciation and extinction. Remote volcanic archipelagoes represent ideal natural laboratories to study biogeography because they offer a discrete temporal and spatial context for colonization and speciation. The moth genus Hyposmocoma is one of very few lineages that diversified across the entire Hawaiian Archipelago, giving rise to over 400 species, including many restricted to the remote northwestern atolls and pinnacles, remnants of extinct volcanoes. Here, we report that Hyposmocoma is B15 million years old, in contrast with previous studies of the Hawaiian biota, which have suggested that most lineages colonized the archipelago after the emergence of the current high islands (B5 Myr ago). We show that Hyposmocoma has dispersed from the remote Northwestern Hawaiian Islands to the current high islands more than 20 times. The ecological requirements of extant groups of Hyposmocoma provide insights into vanished ecosystems on islands that have long since eroded

The Link vs. the Event: Activating and Deactivating Elements in Time-Based Hypermedia

Activation and deactivation of media items plays a fundamental role in the playing of multimedia and time-based hypermedia presentations. Activation and deactivation information thus has to be captured in an underlying document format. In this paper we show that a number of aspects of activation and deactivation information can be captured using both link structures and events in time-based hypermedia. In particular, we discuss how deactivation and activation can be specified, how the activations and deactivations can be initiated and potential (synchronization) relationships between the elements involved. We first introduce the notions of time-based scheduling and event-based scheduling and then present a short summary of linking. We discuss the similarities between event-based scheduling and linking. We describe a number of aspects of activation and deactivation that can be specified within a document. We then discuss how activation and deactivation information can be recorded in link structures and events

Transport of Nordic Seas Overflow Water Into and Within the Irminger Sea: An Eddy-Resolving Simulation and Observations

Results from a climatologically forced, eddy-resolving (1/12 degrees) Atlantic simulation using the Hybrid Coordinate Ocean Model help clarify some presently unresolved connections between volume transports of Nordic Seas overflow water at key locations in the northernmost North Atlantic Ocean. The model results demonstrate that, in addition to the known westward flow through the Charlie Gibbs Fracture Zone (CGFZ), some Iceland Scotland overflow water (ISOW) flows westward through gaps in the Reykjanes Ridge north of the CGFZ into the Irminger Sea, and some flows southward along the eastern flank of the Mid-Atlantic Ridge into the West European Basin. These results provide insights into the well-known inconsistency between observed westward transport of ISOW through the CGFZ (2.4 Sv) and the transports upstream at Southeast of Iceland section (3.2 Sv) and downstream in the western Irminger Sea (4.5 Sv). Although the portion of the simulated ISOW that flows through CGFZ is about 500 m deeper than observed, the model results also show two ISOW pathways of this flow into the Irminger Sea, one northward along the western flank of the Reykjanes Ridge and the other westward before turning north-eastward on the western side of the Irminger Basin. Comparisons with the long-term moored instrument database in the Irminger Sea show that the model-based mean circulation is in reasonable agreement with observed volume transports of overflow water and that it gives approximately correct temperature and salinity characteristics

Структура и твердость титанового сплава ВТ6, изготовленного методом аддитивных технологий

Работа посвящена новой отрасли производства и материаловедения – исследованию материалов, полученных методами аддитивного производства. Целью данной работы являлось сравнительный анализ различий в структуре, механических свойствах и взаимодействии с водородом титанового сплава ВТ6, полученного традиционным методом и методом аддитивного производства (EBM). В работе получены результаты, свидетельствующие об отличии свойств материалов, полученных традиционными методами и методами аддитивного производства.The work is devoted to a new branch of production and materials science - the study of materials obtained by additive production methods. The purpose of this work was a comparative analysis of differences in the structure, mechanical properties and interaction with hydrogen of a titanium alloy VT6 obtained by the traditional method and the additive production method (EBM). The results obtained in the work indicate the difference between the properties of materials obtained by traditional methods and additive production methods

Redshift-independent Distances in the NASA/IPAC Extragalactic Database: Methodology, Content, and Use of NED-D

Estimates of galaxy distances based on indicators that are independent of cosmological redshift are fundamental to astrophysics. Researchers use them to establish the extragalactic distance scale, to underpin estimates of the Hubble constant, and to study peculiar velocities induced by gravitational attractions that perturb the motions of galaxies with respect to the "Hubble flow" of universal expansion. In 2006 the NASA/IPAC Extragalactic Database (NED) began making available a comprehensive compilation of redshift-independent extragalactic distance estimates. A decade later, this compendium of distances (NED-D) now contains more than 100,000 individual estimates based on primary and secondary indicators, available for more than 28,000 galaxies, and compiled from over 2000 references in the refereed astronomical literature. This paper describes the methodology, content, and use of NED-D, and addresses challenges to be overcome in compiling such distances. Currently, 75 different distance indicators are in use. We include a figure that facilitates comparison of the indicators with significant numbers of estimates in terms of the minimum, 25th percentile, median, 75th percentile, and maximum distances spanned. Brief descriptions of the indicators, including examples of their use in the database, are given in an appendix

Structure–function relationships explain CTCF zinc finger mutation phenotypes in cancer

CCCTC-binding factor (CTCF) plays fundamental roles in transcriptional regulation and chromatin architecture maintenance. CTCF is also a tumour suppressor frequently mutated in cancer, however, the structural and functional impact of mutations have not been examined. We performed molecular and structural characterisation of five cancer-specific CTCF missense zinc finger (ZF) mutations occurring within key intra- and inter-ZF residues. Functional characterisation of CTCF ZF mutations revealed a complete (L309P, R339W, R377H) or intermediate (R339Q) abrogation as well as an enhancement (G420D) of the anti-proliferative effects of CTCF. DNA binding at select sites was disrupted and transcriptional regulatory activities abrogated. Molecular docking and molecular dynamics confirmed that mutations in residues specifically contacting DNA bases or backbone exhibited loss of DNA binding. However, R339Q and G420D were stabilised by the formation of new primary DNA bonds, contributing to gain-of-function. Our data confirm that a spectrum of loss-, change- and gain-of-function impacts on CTCF zinc fingers are observed in cell growth regulation and gene regulatory activities. Hence, diverse cellular phenotypes of mutant CTCF are clearly explained by examining structure–function relationships

MINERvA neutrino detector response measured with test beam data

The MINERvA collaboration operated a scaled-down replica of the solid scintillator tracking and sampling calorimeter regions of the MINERvA detector in a hadron test beam at the Fermilab Test Beam Facility. This article reports measurements with samples of protons, pions, and electrons from 0.35 to 2.0 GeV/c momentum. The calorimetric response to protons, pions, and electrons are obtained from these data. A measurement of the parameter in Birks' law and an estimate of the tracking efficiency are extracted from the proton sample. Overall the data are well described by a Geant4-based Monte Carlo simulation of the detector and particle interactions with agreements better than 4%, though some features of the data are not precisely modeled. These measurements are used to tune the MINERvA detector simulation and evaluate systematic uncertainties in support of the MINERvA neutrino cross section measurement program.Comment: as accepted by NIM

Single neutral pion production by charged-current νˉμ\bar{\nu}_\mu interactions on hydrocarbon at ⟨Eν⟩=\langle E_\nu \rangle = 3.6 GeV

Single neutral pion production via muon antineutrino charged-current interactions in plastic scintillator (CH) is studied using the \minerva detector exposed to the NuMI low-energy, wideband antineutrino beam at Fermilab. Measurement of this process constrains models of neutral pion production in nuclei, which is important because the neutral-current analog is a background for $\bar{\nu}_e$ appearance oscillation experiments. The differential cross sections for $\pi^0$ momentum and production angle, for events with a single observed $\pi^0$ and no charged pions, are presented and compared to model predictions. These results comprise the first measurement of the $\pi^0$ kinematics for this process.Comment: 6 pages, 5 figures, submitted to Physics Letters